中国药房2012，Vol.23Issue(47)：4446-4448,3.DOI:10.6039/j.issn.1001-0408.2012.47.12
黄芩苷温敏凝胶在家兔体内的药动学研究
Pharmacokinetic Study of Baicalin Thermosensitive Hydrogel in Rabbits
张磊 1胡霞 2张莉 2仲博 2陈莉 2袁园2
作者信息
- 1. 武警后勤学院附属医院药剂科,天津300162
- 2. 武警后勤学院药剂学教研室,天津300162
- 折叠
摘要
Abstract
OBJECTIVE: To study of Baicalin thermosensitive hydrogel in rabbits after rectal administration. METHODS: Rabbits were given Baicalin thermosensitive hydrogel and water-solubility suppository respectively. Drug concentrations in serum were measured by HPLC. The determination was performed on Shim-pack VP-ODS C18(150 mm×4.6 mm, 5μm) column with mobile phase consisted of methanol-water-phosphoric acid (47: 53: 0.2, V/V/V) at the flow rate of 0.8 mL · min-1. The column temperature was 40 ℃ and injection volume was 10 μL. The detection wavelength was set at 274 nm. RESULTS: The main pharmacokinetic parameters of 2 kinds of preparations were as follows:Cmax: (3.639 ± 0.23) μg-L-1 and (2.832 ± 0.18) μg·L-1; AUCo— (796.46 ± 65,35) μg·h·L-1 and (493.86 ±42.52) μg·h·L-1. Compared with water-solubility suppository,Cmax and AUC0→∞ increased after rectal administration, there was significant difference. Relative bioavailability was 161.2%. CONCLUSION: The bioavailability of Baicalin thermosensitive hydrogel is improved significantly with rectal administration.关键词
黄芩苷/温敏凝胶/药动学/家兔/水溶性栓剂Key words
Baicalin/ Thermosensive hydrogel/ Pharmacokinetics/ Rabbits/ Water-solubility suppository分类
医药卫生引用本文复制引用
张磊,胡霞,张莉,仲博,陈莉,袁园..黄芩苷温敏凝胶在家兔体内的药动学研究[J].中国药房,2012,23(47):4446-4448,3.
