中国药房2013，Vol.24Issue(1)：60-62,3.DOI:10.6039/j.issn.1001-0408.2013.01.21
增效磺胺嘧啶银混悬剂的制备与质量控制
Preparation and Quality Control of Synergist Flamazine Suspension
高新富 1徐彦飞 1丁召兴 1张循格 1边瑞民1
作者信息
- 1. 滨州医学院附属医院,山东滨州 256603
- 折叠
摘要
Abstract
OBJECTIVE: To prepare Synergist flamazine suspension and to establish the method for its quality control. METHODS: Synergist flamazine suspension was prepared with flamazine and trimethoprim. The contents of flamazine and trimethoprim were determined by HPLC and the stability of the preparation was studied. RESULTS: The linear ranges of flamazine and trimethoprim were 20-300 μg/ml and 8-120 μg/ml (both r=0.999 9). Average recoveries were 99.76% (RSD=0.38%) and 100.27% (RSD=0.41% ). Average contents of flamazine and trimethoprim in 3 batches of sample were 49.774 mg/ml and 20.045 mg/ml. The stability of suspension was good in dark place at room temperature within 6 months. CONCLUSION: Preparation technology of Synergist flamazine suspension is reasonable and stable in quality.关键词
增效磺胺嘧啶银混悬剂/甲氧苄啶/制备/质量控制/高效液相色谱法Key words
Synergist flamazine suspension/ Trimethoprim/ Preparation/ Quality control/ HPLC分类
医药卫生引用本文复制引用
高新富,徐彦飞,丁召兴,张循格,边瑞民..增效磺胺嘧啶银混悬剂的制备与质量控制[J].中国药房,2013,24(1):60-62,3.
