中国药房2013，Vol.24Issue(2)：138-140,3.DOI:10.6039/j.issn.1001-0408.2013.02.17
吡格列酮和罗格列酮的人体药动学差异评价
Pharmacokinetics Diversity Evaluation of Pioglitazone and Rosiglitazone in Healthy Volunteers
摘要
Abstract
OBJECTIVE: To study the pharmacokinetics characteristics of representative thiazolidinedione drugs, i.e. pioglitazone and rosiglitazone in healthy volunteers, and to evaluate the individualized dosing regimen. METHODS: 37 healthy volunteers took part in 2 bioavailability tests of pioglitazone and rosiglitazone. Blood concentrations were recorded to study the pharmacokinetics profiles, and the variability of pharmacokinetic parameters in human was investigated. Multiple stepwise regression analysis was used to study the correlation of blood concentration and the exposure of drugs. RESULTS: There were significant differences in pharmacokinetic profiles of pioglitazone and rosiglitazone in human. The average RSD of AUC and t1/2 of pioglitazone were 48.66%-54.04% and 61.31 %-72.54%, respectively; and those of rosiglitazone were 35.37%-48.72% and 24.98%-30.10% , respectively. Multiple stepwise regression analysis showed that there was a good correlation of plasma concentrations during 4 to 8 h and AUC (r>0.9,.P<0.0l). CONCLUSION: There are obvious individual differences of thiazolidinediones drugs in pharmacokinetic profiles, and individual administration may help to improve therapeutic efficacy.关键词
吡格列酮/罗格列酮/人体药动学/个体差异/个体化给药Key words
Pioglitazone/ Rosiglitazone/ Human pharmacokinetics/ Individual differences/ Individual administration分类
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赵莉,崔刚,刘晓,张相林..吡格列酮和罗格列酮的人体药动学差异评价[J].中国药房,2013,24(2):138-140,3.
