中国药房2013，Vol.24Issue(3)：262-264,3.DOI:10.6039/j.issn.1001-0408.2013.03.25
脑心通胶囊治疗血管性痴呆的疗效及对患者氧化应激指标影响的临床观察
Therapeutic Efficacy of Naoxintong Capsules on Vascular Dementia and Effect of It on Oxidative Stress
郭清军 1施雨1
作者信息
- 1. 聊城市第三人民医院,山东聊城250000
- 折叠
摘要
Abstract
OBJECTIVE: To observe the clinical efficacy of Naoxintong capsules in the treatment of mild and moderate vascular dementia (VD) and the effect of it on oxidative stress of patients. METHODS: 78 cases of VD were randomly divided into control group and treatment group with 39 cases in each group. Control group was given Nimodipine tablets 1 piece pertime, 3 times a day and treatment group was given Naoxintong capsule 2-4 pieces each time, 3 times a day . A course of treatment lasted for 6 months. Before and after treatment, Mini-mental state examination scale (MMSE) and Kyohko Hasegawa simple intelligence rating (HDS), activity of daily living scale (ADL) were used to determine oxidative stress index, and clinical efficacy was evaluated by MMSE and symptom improvement, and adverse drug reactions were recorded during treatment. RESULTS: The total effective rate of treatment group was 84.6% , and similar to the control group; MMSE, HDS and ADL score and oxidative stress index of 2 groups were improved after treatment (P<0.05 or P<0.01), and the improvements of MMSE and ADL score, MDA, SOD and GSH-PX activity in treatment group were better than in control group(P<0.01 or P<0.05). Adverse drug reactions were mild in 2 groups. CONCLUSION: Naoxintong capsule can be effectively used in the treatment of mild to moderate VD.关键词
脑心通胶囊/血管性痴呆/疗效/氧化应激Key words
Naoxintong capsule/ Vascular dementia/ Therapeutic efficacy/ Oxidative stress分类
医药卫生引用本文复制引用
郭清军,施雨..脑心通胶囊治疗血管性痴呆的疗效及对患者氧化应激指标影响的临床观察[J].中国药房,2013,24(3):262-264,3.
