中国药房2013，Vol.24Issue(4)：345-346,2.DOI:10.6039/j.issn.1001-0408.2013.04.20
锝[99Tc]亚甲基二膦酸盐联合钙剂、维生素D3治疗原发性骨质疏松症(Ⅰ型)骨转换标志物变化的临床观察
Clinical Observation of 99 Technetium Methylenediphosphonate Combined with Calcium and Vitamin D3 in the Treatment of the Change of Bone Metabolism Markers Caused by Primary Osteoporosis (Type Ⅰ)
郑飞波 1王明民 1柳炳吉 1朱文茹 1梁杰 1于华1
作者信息
- 1. 青岛大学医学院第二附属医院核医学科,山东青岛266042
- 折叠
摘要
Abstract
OBJECTIVE: To observe the change of bone metabolism markers caused by primary osteoporosis treated with 99 technetium methylenediphosphonate combined with calcium and vitamin D3. METHODS: 60 patients suffered from primary osteoporosis (type I ) were randomized into treatment group and control group with 30 cases in each group. Control group were treated with vitamin D3 (1 μg/d) and Caltrate with vitamin D tablets (600 mg/d) for 150 days. Based on the therapeutic regimen of control group, treatment group were treated with 99 technetium methylenediphosphonate 22 mg/d intravenous drip for 10 days, subsequently with an intermission for 15 days, repeated 6 cycles. The markers of bone metabolism (urine Dpd and NTX, BALP and BGP) were detected and compared separately in different period of pre-therapy, 3 months or 5 months after treatment. The incidence of adverse drug reactions were observed in 2 groups. RESULTS: The levels of markers in treatment group decreased obviously after treatment, compared with in corresponding control group; there was statistical significance (P<0.05). The change of urine Dpd, NTX, BALP and BGP in treatment group surpassed obviously in control group; there was statistical significance (P<0.05). No adverse drug reaction was found in 2 groups. CONCLUSION: The combination therapy of 99 technetium methylenediphosphonate, calcium and vitamin D3 is effective and safe in lowering the rate of bone turnover, increasing bone quality and improving life quality of patients with primary osteoporosis.关键词
锝[99Tc]亚甲基二膦酸盐/钙剂/维生素D3/原发性骨质疏松症/骨转换标志物Key words
99 technetium methylenediphosphonate/Calcium carbonate/Vitamin D3/Primary osteoporosis/Markers of bone metabolism分类
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郑飞波,王明民,柳炳吉,朱文茹,梁杰,于华..锝[99Tc]亚甲基二膦酸盐联合钙剂、维生素D3治疗原发性骨质疏松症(Ⅰ型)骨转换标志物变化的临床观察[J].中国药房,2013,24(4):345-346,2.
