摘要
Abstract
OBJECTIVE: To evaluate the efficacy and safety of statins on normolipidemic patients with isolated systolic hypertension (ISH). METHODS: We searched Pubmed, EMbase, Controlled Trials of Cochrane Library, CBM, CNKI and Wanfang database from the date of establishment to May 2012. We also researched relevant journals and conference proceedings by hand. RCTs about statins for normolipidemic patients with isolated systolic hypertension were collected. After quality evaluation and data extraction, Meta-analysis of included literatures was conducted using Rev Man 5.0 software. RESULTS: A total of 17 RCTs were included, involving 1 297 patients. Meta-analysis showed that statins group was more effective than control group in lowering SBP levels [MD=-4.56, 95%CI(-5.60,-3.53),P<0.000 01], PP levels[MD=-8.41, 95%CI( -10.44, -6.38) ,P<0.000 01]; while statins group was more effective than control group in preventing the decrease of DBP levels[MD=3.26, 95%CI(1.42,5.09) ,P= 0.000 5]; there was no significant difference between the 2 groups in TC levels, TG levels, LDL-C levels, HDL-C levels and the incidence of adverse drug reactions. CONCLUSION: For normolipidemic patients with ISH, statins are effective in lowering SBP levels, PP levels with less adverse drug reactions.关键词
他汀类药物/单纯收缩期高血压/Meta分析Key words
Statins/Isolated systolic hypertension/Meta-analysis分类
医药卫生
