中国药房2013，Vol.24Issue(5)：410-411,2.DOI:10.6039/j.issn.1001-0408.2013.05.10
高蛋白饮食对犬体内左氧氟沙星药动学的影响研究
Effects of High Protein Diet on the Pharmacokinetics of Levofloxacin in Dogs
岳建农 1李飞 1罗斌1
作者信息
- 1. 重庆市黔江中心医院药剂科,重庆409000
- 折叠
摘要
Abstract
OBJECTIVE: To study the effects of high protein diet on the pharmacokinetics of levofloxacin in dogs. METHODS: 6 dogs were randomly divided into fasting group and high protein diet group; high protein diet group received high protein diet 150 g in each; both groups were given levofloxacin 10 mg/kg. The blood concentration of levofloxacin in dogs was determined by HPLC 0.5, 1,2,4, 8, 12, 24 and 48 h after medication, randomly crossed experiments were carried out 2 weeks later; and pharmacokinetic parameters were calculated with 3p97 software. RESULTS: Pharmacokinetics process of Levofloxacin in 2 groups dogs were in accordance with the two compartment model. Main pharmacokinetic parameters of fasting group vs. protein group were as follows:/^: (11.07 ± 8.46) h vs.(21.65 ± 4.65) h;tmax (3.42 ± 0.41) h vs.(1.53 ± 0.34) h;cmax: (2.71 ± 0.60) ug/ml vs. (2.22 ±0.22) μg/ml; AUC0-48 h:(36.51 ±8.66) μg·h/ml vs.(29.78±4.26) ug-h/ml, respectively. There was significant difference in tmax (P<0.01) , while other parameters had no significant difference between 2 groups (P>0.05). CONCLUSIONS: High protein diet can reduce tmax, promote absorption of levofloxacin.关键词
高蛋白饮食/左氧氟沙星/药动学/犬Key words
High protein diet/ Levofloxacin/ Pharmacokinetics/ Dogs分类
医药卫生引用本文复制引用
岳建农,李飞,罗斌..高蛋白饮食对犬体内左氧氟沙星药动学的影响研究[J].中国药房,2013,24(5):410-411,2.
