摘要
Abstract
OBJECTIVE: To study the inhibitory effects of simvastatin on cardiovascular remodeling of hypertensive model rats and its mechanism. METHODS: 60 rats were randomly divided into model group and negative control group. Hypertensive model was established for rats continuously for 3 weeks in model group, the changes of blood pressure and aortic structure were detected and mRNA and protein expression of RhoA were determined. And then model group were divided into simvastatin low-dose, medium-dose and high-dose groups (0.1, 1, 10 mg/kg) (n=9); 9 rats in negative control group were included in control group. They were given relevant medicine once a day, and 8 weeks later they were scarificed. The changes of aortic structure, mRNA and protein expression of RhoA were determined in 4 groups. RESULTS: Compared with negative control group, systolic blood pressure, diastolic blood pressure, mRNA and protein expression of RhoA were increased significantly in model group (P<0.01), and hypertensive model was established successfully through aortic intimal hyperplasia and intimal thickness broadening. Compared with control group, aortic intimal hyperplasia, mRNA and protein expression of RhoA were decreased significantly in low-dose, medium-dose and high-dose groups (P<0.05), in dose-dependant manner. CONCLUSIONS: Simvastatin can inhibit the cardiovascular remodeling of hypertensive rats by Rho/Rho kinase signal pathway.关键词
Rho/Rho激酶信号通路/Rho激酶/大鼠/主动脉/血管重构/辛伐他汀Key words
Rho/Rho kinase signal pathway/ Rho kinase/ Rats/ Aortic/ Vascular remodeling/ Simvastatin分类
医药卫生
