中国药房2013，Vol.24Issue(7)：639-641,3.DOI:10.6039/j.issn.1001-0408.2013.07.23
血栓心脉宁片的HPLC-ELSD指纹图谱研究
Fingerprint of Xueshuan Xinmaining Tablet by HPLC-ELSD
明磊 1林美妤 1张庆贺 1刘海宇 1卢丹 1李平亚 1刘金平1
作者信息
- 1. 吉林大学再生医学科学研究所,长春130021
- 折叠
摘要
Abstract
OBJECTIVE: To establish fingerprint of Xueshuan xinmaining tablet by using HPLC-ELSD. METHODS: The analysis was performed on Diamonsil C18 column (250 mm×4.6 mm,5 μm) with mobile phase consisted of acetonitrile-1% acetic acid (gradient elution) at the flow rate of 1.0 ml/min. ELSD method was used; the data were analyzed by chromatographic fingerprint evaluation system (2004A version). RESULTS: 17 common peaks were found in HPLC-ELSD fingerprints of 10 batches of Xueshuan xinmaining tablet. In precision, reproducibility and stability test, RSDs of relative peak area and relative retention time of common peaks were less than 4%. The similarities of 10 batches of samples were between 0.880 and 1.000. CONCLUSION: The method is simple, accurate and reproducible, and it is suitable for the quality control of Xueshuan xinmaining tablet. It provides basis for the further study of Xueshuan xinmaining tablet.关键词
血栓心脉宁片/指纹图谱/高效液相色谱-蒸发光散射检测器法Key words
Xueshuan xinmaining tablet/ Fingerprint/ HPLC-ELSD分类
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明磊,林美妤,张庆贺,刘海宇,卢丹,李平亚,刘金平..血栓心脉宁片的HPLC-ELSD指纹图谱研究[J].中国药房,2013,24(7):639-641,3.
