中国药房2013，Vol.24Issue(8)：711-713,3.DOI:10.6039/j.issn.1001-0408.2013.08.14
氟哌噻吨美利曲辛联合埃索美拉唑治疗非糜烂性胃食管反流病的临床观察
Clinical Observation of Flupentixol Melitracen Combined with Esomeprazole in the Treatment of Non-erosive Gastroesophageal Reflux Disease
季兴 1黄薇薇 1程莉华 1潘程宇2
作者信息
- 1. 南京医科大学附属南京儿童医院药学部,南京210008
- 2. 江苏省中西医结合医院消化科,南京210028
- 折叠
摘要
Abstract
OBJECTIVE: To observe the clinical efficacy of flupentixol melitracen combined with esomeprazole in the treatment of non-erosive gastroesophageal reflux disease (NERD). METHODS: 84 cases of NERD collected from a hospital during Jan. 2009 - Jun. 2011 were randomly divided into observation group and control group. Observation group accepted flupentixol melitracen combined with esomeprazole, and control group received esomeprazole. Therapeutic efficacy and adverse drug reaction were compared between 2 groups. RESULTS: After treatment, heartburn, pectoralgia and sour regurgitation were improved; there was statistical significance (P<0.05). The effective rate of observation group was 90.5% (38/42) , and that of control group was 54.8% (23/42) ; there was statistical significance (P< 0.05). The incidence of ADR was 2.4% in observation group (1/42) and 11.9% in control group (5/42) ; there was no statistical significance (P>0.05). The follow-up period lasted for 6 months-18 months. The recurrent rate of observation group was 9.5% (4/42) and that of control group was 31.0% (13/42); there was statistical significance (P< 0.05). CONCLUSION: Combined treatment of flupentixol melitracen and esomeprazole can intervene in the quality of life and mental psychological abnormality in NERD patients through psycho-mental factors, improve therapeutic efficacy and reduce recurrence. It helps clinical physicians intervene in NERD, which deserves further attention.关键词
埃索美拉唑/非糜烂性胃食管反流病/氟哌噻吨美利曲辛Key words
Esomeprazole/ Non-erosive gastroesophageal reflux disease/ Flupentixol melitracen分类
医药卫生引用本文复制引用
季兴,黄薇薇,程莉华,潘程宇..氟哌噻吨美利曲辛联合埃索美拉唑治疗非糜烂性胃食管反流病的临床观察[J].中国药房,2013,24(8):711-713,3.
