中国医科大学学报2012，Vol.41Issue(11)：1018-1021,4.
阿魏酸川芎嗪后处理对大鼠心肌缺血再灌注损伤的影响
Effects of Ligustrazine Ferulate Postconditioning on Myocardial Ischemia Reperfusion Injury in Rats
摘要
Abstract
Objective To investigate the effects of ligustrazine ferulate (LF) postconditioning on myocardial ischemia reperfusion injury in rats,and explore the related mechanisms. Methods Forty-eight male rats were randomly divided into sham-operation (SM) group,ischemia reperfusion (I/R) group,ligustrazine (LZ) group,LF group. The rat model of myocardial I/R was established by occlusion of the left anterior descending coronary artery for 30 minutes and reperfusion for 120 minutes. Rats in LZ group and LF group received jugular vein injection of LZ and LF (40 mg/kg) before reperfusion. The rats of SM group were given only loose suture around IAD. The parameters of haemodynam-ics was record; superoxide dismutase (SOD), malondialdehyde (MDA ) in serum, myocardial infarct size, myocardial apoptosis index and the expression of Fas protein were measured. Results Compared with I/R group,HR was accelerated,LVESP and 眃p/dtmax was enhanced, LVEDP was reduced,SOD activity was increased,MDA content was decreased in LF group and LZ group (P < 0.01 );in addition,myocar-dial infarct size, myocardial apoptosis index and the expression of Fas protein all were reduced (P < 0.01 ). The effect of LF is stronger than LZ about aforesaid indicators, the difference had statistical significance (P < 0.05). Conclusion LF postconditioning can protect against myocardial I/R injury,and the protective effect may be related to the scavenging of oxide free radical,which further restrain the reaction of lipid peroxidation and apoptosis.关键词
阿魏酸川芎嗪/缺血后处理/心肌缺血再灌注损伤/细胞凋亡/Fas蛋白Key words
ligustrazine ferulate/ischemia postconditioning/myocardial ischemia-reperfusion injury/apoptosis/Fas protein分类
医药卫生引用本文复制引用
赵润英,郝伟,孟祥军,李昭,赵丽妮,马明洋,丁双双..阿魏酸川芎嗪后处理对大鼠心肌缺血再灌注损伤的影响[J].中国医科大学学报,2012,41(11):1018-1021,4.基金项目
沈阳市科技局科技计划项目(F10-149-9-16) （F10-149-9-16）
