中国医科大学学报2012，Vol.41Issue(11)：1030-1033,1040,5.
Graves甲亢患者131I治疗3个月后甲状腺激素和TSH水平对患者预后的评估作用
The Predictive Value of the Serology Analysis at 3rd Month after Radioiodine Treatment in Graves' Hyperthyroidism Patients
摘要
Abstract
Objective To evaluate the clinical predictive value of the serology at 3rd month after the radioiodine treatment in Graves' hy-perthyroidism patients. Methods A tolal of 258 patients with Craves' disease (GD) treated with 131Ⅰ between March 2008 and October 2010 were recruited for the study,and these patients were followed for 3 and 6 months or longer after treatment. The age range was 15 to 86 years and the dosage range was 74-407 MBq (2-11 mCi). According to the inspection of thyroid hormone and TSH at 3rd month after treat-ment, the patients were divided into improved,clinical cure,hypothyroid Ⅰ (free T4 decreased,and TSH≤10 mlU/L),hypothyroid II (free T4 decreased,and TSH> 10 mIU/L) and invalid groups. The incidence of hypothyroid,clinical cure,hyperthyroid recurrence and transient hy-pothyroid were compared among the 5 groups. Results The incidence of hypothyroid among the 5 groups were signiiieandy different (x2= 69.14,P =0.000). The difference of hyperthyroid recurrence between the clinical cure,hypothyroid I and Ⅱ groups was not significant (x2= 5.690,P =0.058). There was no significant difference of hypothyroid incidence between improved and invalid groups,cure and hypothyroid I groups ( V =698,P =0.75); U =707,P =0.130). The incidence of transient hypothyroid between hypothyroid I and Ⅱ groups was significant ( U =774, P =0.046). Conclusion The results indicated that the serology at 3rd month after radioiodine treatment had important predictive value for Graves' hyperthyroidism patients.关键词
Graves甲亢/131I/治疗Key words
Graves' hyperthyroidism/131Ⅰ/treatment分类
医药卫生引用本文复制引用
尹雅芙,李亚明,陈松,杜补林,李娜,李雪娜,刘一,王颖,王晓蓓,蒋宁一..Graves甲亢患者131I治疗3个月后甲状腺激素和TSH水平对患者预后的评估作用[J].中国医科大学学报,2012,41(11):1030-1033,1040,5.基金项目
卫生部公益性卫生行业科研专项项目(2-29) （2-29）
