中国药理学与毒理学杂志2013，Vol.27Issue(1)：106-109,4.DOI:10.3867/j.issn.1000-3002.2013.01.020
脂多糖/Toll样受体4信号转导与肝纤维化的研究进展
Progress in lipopolysaccharide/Toll-like receptor 4 signaling transduction in hepatic fibrosis
摘要
Abstract
Toll-like receptor 4(TLR4) is one of the pattern recognition receptors. It acts as a receptor for lipopolysac- charide, a cell-wall component of Gram-negative bacteria. The innate and adaptive immune responses are initiated by li-popolysaccharide binding to TLR4 so as to effectively reduce microorganism invasion. In the liver, all parenchyma cells and nonparenchymal cells can express TLR4. In recent years, there is growing evidence that some cells in the liver, such as hepatic stellate cells, Kupffer cells and dendritic cells, can release many kinds of cytokines through lipopolysaccharide/ TLR4 signal transduction, causeing a series of pathological changes so as to participate in the pathogenesis of hepatic fibrosis.关键词
Toll样受体4/脂多糖/信号转导/肝纤维化Key words
Toll-like receptor 4/ lipopolysaccharide/ signaling transduction/ hepatic fibrosis/ hepatic stellate cells/ Kupffer cells分类
医药卫生引用本文复制引用
朱晓静,张峰,孔德松,陆茵,王爱云,陈文星,郑仕中..脂多糖/Toll样受体4信号转导与肝纤维化的研究进展[J].中国药理学与毒理学杂志,2013,27(1):106-109,4.基金项目
国家自然科学基金资助项目(30873424) （30873424）
国家自然科学基金资助项目(81270514) （81270514）
国家十一五支撑计划项目(2008BAI51B02) （2008BAI51B02）
南京中医药大学中药学一级学科开放课题项目(2011ZYX4-008) （2011ZYX4-008）
教育部博士点基金资助项目(20103237110010) （20103237110010）
江苏省自然科学基金资助项目(BK2008456) （BK2008456）
江苏省六大人才高峰资助项目(2009112) （2009112）
江苏高校优势学科建设工程资助项目(ysxk-2010) （ysxk-2010）
江苏省针灸学重点实验室开放课题(KJA200801) （KJA200801）
