中国药理学与毒理学杂志2013，Vol.27Issue(1)：119-122,4.DOI:10.3867/j.issn.1000-3002.2013.01.023
ficolins基因多态性与临床疾病易感性的研究进展
Progress of genetic polymorphism in ficolins and disease susceptibility
摘要
Abstract
Ficolins are pattern-recognition molecules, which were originally identified as transforming growth factor β1 -binding proteins on porcine uterus membranes. The human ficolins, similar to the mannan-binding lectin, can bind to N-acetylglucosamine (GlcNAc) on the microbial cells and appear to be of major importance for innate immunity and tissue homeostasis. Three ficolin genes have been identified in humans: FCN1, FCN2 and FCN3, which encode M-ficolin, L-fi-colin and H-ficolin respectively. Recently, the role of the ficolins gene in disease has been emphasized. This review focuses on the recently discovered genetic polymorphism in FCN and the susceptibility of relative diseases.关键词
ficolins/基因多态性/疾病易感性Key words
ficolins/ genetic polymorphism/ disease susceptibility分类
医药卫生引用本文复制引用
张涛,周宏灏..ficolins基因多态性与临床疾病易感性的研究进展[J].中国药理学与毒理学杂志,2013,27(1):119-122,4.基金项目
国家自然科学基金(81102511) （81102511）
重庆市自然科学基金(cstc2011jjA10004) （cstc2011jjA10004）
中国博士后科学基金(2011M500669) （2011M500669）
重庆市博士后科研项目特别资助项目(渝xm201102007) （渝xm201102007）
