中国药业2012，Vol.21Issue(24)：72-73,2.
盐酸川芎嗪滴丸制备工艺研究
Study on Preparation Technology of Ligustrazine Hydrochloride Dropping Pills
苏春梅 1杨红 1朱爱民 2梁翠茵 1姚金风1
作者信息
- 1. 首都医科大学燕京医学院,北京,101300
- 2. 北京市顺义区中医医院药剂科,北京,101300
- 折叠
摘要
Abstract
Objective To study the different factors influencing the dropping pill formation and to optimize the formation technology. Methods The dissolution time - limit, appearance quality and weight variation were used as the comprehensive evaluation indicators to optimize the technology of prescriptions and dropping pill formation. Results The optimized dropping technological conditions were as follows: with PEG4000 + PEG6000( 1 : 1 ) as the base material, the matching proportion of drugs and base material was 1 : 4, the dripping temperature was 90 ℃, the dropping speed was 40 drop/min and the dropping distance was 8 cm. Conclusion This technology is simple and feasible. The evaluation indexes are reliable and reasonable, and meet the requirement for dripping pills specified in the Chinese Pharmacopeia ( Edition 2010 ).关键词
盐酸川芎嗪/滴丸/制备工艺/正交试验Key words
ligustrazine hydrochloride/ dropping pills/preparation technology/ orthogonal design分类
化学化工引用本文复制引用
苏春梅,杨红,朱爱民,梁翠茵,姚金风..盐酸川芎嗪滴丸制备工艺研究[J].中国药业,2012,21(24):72-73,2.
