中国药业2013，Vol.22Issue(4)：37-38,2.
顶空毛细管气相色谱法测定碘佛醇原料药中的残留溶剂
Determination of Residual Solvents in Ioversol Raw Material Drug by Headspace Capillary Gas Chromatography
李超 1张勉 1唐华1
作者信息
- 1. 重庆市食品药品检验所,重庆,401121
- 折叠
摘要
Abstract
Objective To establish the headspace capillary gas chromatographic method for the content determination of residual solvents such as methanol and n - butanol in ioversol raw material drug. Methods Methanol and n - butanol in ioversol raw material drug were determined by the headspace gas chromatography with the ZB - WAX capillary column(30 m×0. 32 mm,0.25 μm). Results Methanol and n - butanol showed the linear relation within the concentrations of 122.2-366.6 μg/mL(r = 0. 998 3) and 128.4-385.2 μg/mL ( r = 0. 999 3 ), respectively. The mean recovery rates were 102. 86% ( n = 9, RSD = 1. 43% )and 96. 68% ( n = 9, RSD = 2. 69% ), respectively. The detection limits were 0.66 μg/mL and 0.04 μg/mL. Conclusions This established method is simple,sensitive,accurate and reliable for the content determination of residual solvents in ioversol raw material drug and the quality control of this product.关键词
碘佛醇/残留溶剂/毛细管气相色谱/顶空进样Key words
ioversol/residual solvents/capillary gas chromatography/headspace injection分类
医药卫生引用本文复制引用
李超,张勉,唐华..顶空毛细管气相色谱法测定碘佛醇原料药中的残留溶剂[J].中国药业,2013,22(4):37-38,2.
