肿瘤防治研究2012，Vol.39Issue(11)：1365-1368,4.DOI:10.3971/j.issn.1000-8578.2012.11.021
21例毛细胞白血病临床分析
Analysis of Clinical Features in 21 Patients with Hairy Cell Leukemia
王慧 1李凯敏 1王笑蕾 1刘英慧 1黄葆华 2秦友平1
作者信息
- 1. 264000山东烟台,青岛大学医学院附属烟台毓璜顶医院血液内科
- 2. 264000山东烟台,青岛大学医学院附属烟台毓璜顶医院检验科
- 折叠
摘要
Abstract
Objective To investigate the clinical and therapeutic effects of hairy cell leukemia(HCL). Methods The clinical and laboratory characteristics of twenty-one patients with HCL were retrospectively analysed. Results Splenomegaly was the most common physical phenomenon. The others were pancytopenia and active bone marrow hyperplasia. Ribosomal-lamellae only accounted for a few patients. Classic HCL cell expressed CDllc,CD25,CD123,CD103, and companied with CD20,CD22,CD52 and Cyclin Dl expression. Especially,CD103 was HCL specific immunophenotype. The purine nucleoside analogues presented better therapeutic effects than other regiments. Conclusion The HCL clinical characteristics are similar to that in western patients. In Chinese patients fludarabine-based combination regimens has no significant accumulation of bone marrow inhibition,and the therapeutic effect is higher than that in foreign patients.关键词
毛细胞白血病/临床特点/免疫表型/核苷类似物Key words
Hairy cell leukemia/Clinical feature/Immunophenotype/Nucleoside analogues分类
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王慧,李凯敏,王笑蕾,刘英慧,黄葆华,秦友平..21例毛细胞白血病临床分析[J].肿瘤防治研究,2012,39(11):1365-1368,4.
