肿瘤防治研究2012，Vol.39Issue(12)：1451-1455,5.DOI:10.3971/j.issn.1000-8578.2012.12.011
STAT-3与Enolase-1在乳腺癌组织中的表达及意义
Expression and Clinical Signifiance of STAT-3 and Enolase-1 in Breast Cancer
摘要
Abstract
Objective To investigate the expression of STAT-3 and Enolase-1 in breast cancer and its relationship with Estrogen receptor status, Progesterone receptor status, lymph node metastasis, clinical stages and histological grading. Methods The expression of STAT-3 and Enolase-1 were examined by im-munohistochemical streptavid-peroxidase(S-P)assay in 126 cases of breast cancer and 26 cases of benign breast disease. And the significance of its expression was analyzed with clinicopathologic parameters. Results The expression rates of STAT-3(77. 8%)and Enolase-1 (82. 5%)in breast cancer were significantly higher than that in benign breast diseaseC 11.5% vs. 7. 7%)and the expression of two proteins were positively correlated(x2 = 42. 416,P<0. 05;x2 = 57. 211 ,F<0. 05). The expression of STAT-3 and Enolase-1 in breast cancer has no significant difference in age, tumor size,histologic grading and clinical stages. Epression of STAT-3(85. 7%)and Enolase-1 (90. 5%)in breast cancer with metastasis is significantly higher than that without metastasis (x2=9. 184,P<0.05;X2 = 11. 014,P<0. 05). There was a significant correlation between the high expression of STAT-3 and axillary lymphatic metastasis in comparisons between positive estrogen and/or progesterone receptor expression and Her-2 positive expression(P<0. 05). And there was a significant correlation between the high expression of Enolase-1 and axillary lymphatic metastasis in comparisons with positive estrogen or positive progesterone receptor expression and Her-2 positive expression( P<0. 05). Conclusion Both STAT-3 and Enolase-1 may be involved in the tu-morgenesis development and metastasis of breast cancer. The high expression of STAT-3 and Enolase-1 in estrogen receptor or/and progesterone receptor or Her-2 positive breast cancer was associated with a high possibility of lymph node metastasis. The detection of STAT-3 and Enolase-1 may be helpful in the diagnosis and prognosis of breast cancer.关键词
乳腺肿瘤/淋巴结转移/STAT-3/Enolase-1Key words
Breast cancer/ Lymph node metastasis/STAT-3 / Enolase-1分类
医药卫生引用本文复制引用
杨洁,吴明富,叶双梅,蒋学锋,马全富,阚淳一,杨丽兰,卢运萍,王世宣,马丁..STAT-3与Enolase-1在乳腺癌组织中的表达及意义[J].肿瘤防治研究,2012,39(12):1451-1455,5.基金项目
教育部新教师基金资助项目(200804871056) （200804871056）
