肿瘤防治研究2012，Vol.39Issue(12)：1482-1486,5.DOI:10.3971/j.issn.1000-8578.2012.12.018
颅内血管周细胞瘤fMRI及病理组织学特征分析
Functional MRI and Histopathology of Intracranial Hemangiopericytomas
邓晓娟 1肖华亮 2王舒楠 1罗清雅 2张玉龙 1张伟国1
作者信息
- 1. 400042重庆,第三军医大学大坪医院野战外科研究所放射科
- 2. 400042重庆,第三军医大学大坪医院外科研究所病理科
- 折叠
摘要
Abstract
Objective To evaluate the normal and advanced MR features, pathological features of intracranial hemangiopericytomas in order to improve its diagnostic accuracy. Methods The normal and advanced MRI findings, pathological findings of 7 cases with intracranial hemangiopericytomas verified by pathology were retrospectively analyzed. Results MRI features of intracranial HPC included: 7 cases all were Outside brain parenchyma with average diameter (6. 3 ± 1.2) cm of focus area. Among the 7 cases, 6 of the cases were multilobulated, 7 were narrow based with dural, 4 had serpentine signal voids, and 6 had cystic degeneration or necrosis. The mix- intensity of T1WI, T2WI and T2WI-Flair markedly enhancement, showing a mild- moderate peritumoral edema around the tumor. The results from hyper- hetero-genous intensity of DWI[ADC value was (1. 15 ±0.36)] and of PWI [rCBV was (7. 52 ± 1. 93); rCBF was (8. 73 ± 1. 78) ; and MTT was (1. 62 ± 0. 29)]demonstrated a high perfusion in the tumor. The necrosis area showed low perfusion or no perfusion, while the peritumoral edema showed low perfusion. The results from MRS demonstrated that Cho/NAA, Cho/Cr, MI /N MI(normal MI) and Lac/Cr have significantly become higher and NAA /Cr has significantly become lower. Pathologically, tumors contained a large number of staghorn vessels with separated lobulations, oval shape tumor cells, and rich reticular fibers. Immunohistochemisty: 7 cases CD34( + ), 5 cases EMA( - ), 5 cases PR( - ), 5 cases SMA ( - ), 4 cases GFAP( - ),4 cases S- 100 ( - ). Ki - 67 ≤5% 3 cases, ≤10% 2 cases, and <20% 2 cases. Conclusion The morphology changes exhibited correlations with the information based on DWI, PWI and MRS for the patients with intracranial hemangiopericytomas. Thus, the application of multiple MIR plays an important role in the diagnosis and identification of intracranial hemangiopericytomas.关键词
血管周细胞瘤/功能磁共振成像/病理组织学Key words
Hemangiopericytomas/Functional magnetic resonance imaging/ Histopathology分类
医药卫生引用本文复制引用
邓晓娟,肖华亮,王舒楠,罗清雅,张玉龙,张伟国..颅内血管周细胞瘤fMRI及病理组织学特征分析[J].肿瘤防治研究,2012,39(12):1482-1486,5.
