中山大学学报（医学科学版）2013，Vol.34Issue(1)：89-93,5.
不同氧浓度对单精子卵浆内注射技术胚胎发育及妊娠结局的影响
Effect of Oxygen Concentration on Outcome of Women Undergoing ICSI and Embryo Transfer
摘要
Abstract
[ Objective ] To investigate the effect of incubator oxygen concentration on the embryo development and outcome of women undergoing ICSI and embryo transfer. [Methods] A total of 645 ICSI cycles with fresh embryo transfer conducted in the First Affiliated Hospital of Sun Yat-sen University during January 2011 to December 2011 were retrospectively analyzed. According to the oxygen concentration during day 1-3 in vitro culture, cycles were classified as 5% oxygen concentration group and 20% oxygen concentration group. Day 3(D3) transfer embryo score and clinical outcomes were measured. [Result] Viable embryo rate (72.02% versus 68.73) and mean score of transfer embryo (22.53 versus 20.10) in D3 culture were higher in low oxygen group while all clinical outcomes were similar. Cumulative pregnancy rate (60.44% versus 51.67%) was higher in lower oxygen group. To subgroup cycles with poor prognosis, mean score of transfer embryo (20.66 versus 16.71) , viable embryo rate (76.11% versus 64.55%) and implantation rate (22.27% versus 10.08%) was significantly higher in low oxygen group. [Conclusion] In vitro culture of embryos deriving from ICSI in 5% oxygen concentration during the first 3 days is superior to culture in 20% oxygen concentration.关键词
氧浓度/ICSI/体外受精/胚胎移植Key words
oxygen concentration/ ICSI/ in vitro fertilization/ embryo transfer分类
医药卫生引用本文复制引用
杨雨,徐艳文,李涛,丁晨晖,刘瑜亮,袁媛,周灿权..不同氧浓度对单精子卵浆内注射技术胚胎发育及妊娠结局的影响[J].中山大学学报（医学科学版）,2013,34(1):89-93,5.基金项目
国家"973"科技计划课题(2007CB948103) （2007CB948103）
广东省科技计划项目(2008A030201028) （2008A030201028）
