中山大学学报（医学科学版）2013，Vol.34Issue(1)：94-98,5.
早期妊娠自然流产患者的超声表现与绒毛染色体核型分析
Karyotype Analysis on Chorionic Villus of Early Pregnancy Loss in Relation to Different Ultrasound Findings
摘要
Abstract
[ Objective ] To compare the chromosomal karyotype of chorionic villus in early pregnancy loss in relation to different ultrasound findings. [Methods] From January 2008 to December 2011, 183 patients with early pregnancy loss were evaluated by regular ultrasound and human chorionic gonadotrophin (HCG) during pregnancy and karyotyping was performed on chorionic villus after curettage. The proportion and type of chromosomal anomalies in two groups defined by presence or absence of cardiac activity before miscarriage were compared. [Results] Of the 183 samples from early spontaneous abortion, 109 cases (59.6%) were abnormal karyotype, 74 cases (40.4%) were normal karyotype. Chromosomal abnormality rate was similar for miscarriage with absent or present cardiac activity (61.8% vs 56.8%) , (P ＞ 0.05). Frequencies for viable autosomal trisomies, (45,X) , triploidy in miscarriage with presence of cardiac activity were significantly higher than that of absence of cardiac activity (46.0% vs 6.5%), (P ＜ 0.05). The most frequent chromosomal anomalies in miscarriage with presence of cardiac activity were (45, X) , triploidy and trisomy 16. While trisomy 16 was most frequent in miscarriage with absence of cardiac activity. No (45,X) and triploidy were found in this group. In present with cardiac activity group, the embryonic pole was larger in viable autosomal trisomies, (45,X), triploidy group (17.7 ± 6.4 mm) than that of other chromosomal anomaly (8.8+5.3 mm) and normal karyotype (11.1 ± 8.4 mm).[Conclusion] Chromosomal anomaly is a major reason of early spontaneous abortion. Viable autosomal trisomies, (45 ,X) , triploidy is more frequent in spontaneous abortion after demonstration of cardiac activity.关键词
自然流产/绒毛/染色体核型分析/超声Key words
spontaneous abortion/ chorionic villus/ karyotype analysis/ ultrasound分类
医药卫生引用本文复制引用
刘玉昆,刘颖琳,杜涛,陈立斌,刘梅兰,陈慧,谭剑平,张建平..早期妊娠自然流产患者的超声表现与绒毛染色体核型分析[J].中山大学学报（医学科学版）,2013,34(1):94-98,5.基金项目
国家自然科学基金(81170625) （81170625）
广东省自然科学基金博士启动项目(06021369) （06021369）
