中国中西医结合杂志2013，Vol.33Issue(1)：100-104,5.
复健片促进脑梗死大鼠运动功能康复和神经再生的作用
Promotion of Compound Fujian Tablet on the Motor Function Rehabilitation and Neurotization in Rats with Cerebral Infarction
摘要
Abstract
Objective To study the effects of Compound Fujian Tablet (FJT)on the neurotization in the cerebral infarction rats and to explore its mechanisms for promoting the motor skills. Methods Totally 90 Wistar rats were randomly divided into the drug group, the model group, and the sham-operation group, 30 in each group. The rat model of middle cerebral artery occlusion (MCAO)was successfully established by electrocoagulation. Six hours after successful modeling, the rats of the drug group were orally administered with 9 g/kg FJT water solution, and the other groups were orally administered with equal volume of normal saline, once a day for two weeks. The motor skills of rats were examined by beam walking test. The expressions of nestin, polysialic acid neural cell adhesion molecule (PSA-NCAM), mi-crotubule-associated protein 2 ( MAP-2 ), growth-associated protein ( GAP- 43 ), and synaptophysin (Syn)in the brain tissue around the infarction were observed by in immunohistochemical assay. The mean staining gray or the optical density value were detected. Results The 86 rats were recruited in the result analysis. After two weeks of administration, the neural function scoring was obviously higher in the drug group than in the model group with statistical difference (P<0. 01 ).The expressions of nestin, PSA-NCAM, MAP-2, GAP-43, and Syn in the brain tissue around the infarction were more obviously enhanced in the drug group than in the model group, showing statistical difference (P <0. 01). Conclusion FJT can promote neurotization and improve the motor skill recovery after cerebral infarction.关键词
中药复健片/脑梗死/神经再生Key words
Compound Fujian Tablet/ cerebral infarction/ neurotization引用本文复制引用
周永红,胡怀强,王新陆..复健片促进脑梗死大鼠运动功能康复和神经再生的作用[J].中国中西医结合杂志,2013,33(1):100-104,5.基金项目
国家自然基金资助项目(No.30672745) （No.30672745）
山东省科技发展计划资助项目(No.2006GG3202005) （No.2006GG3202005）
