中药材2012，Vol.35Issue(9)：1450-1455,6.
鸡骨草防治大鼠脂肪肝的实验研究
Experimental Research on Prevention and Treatment of Fatty Liver Rats with Abrus cantoniensis
摘要
Abstract
Objective:To investigate the effects of Abrus cantoniensis( AC) on blood lipid metabolism,pathomorphological change of the liver and fenestrae of liver sinus endothelial cell( LSEC) in fatty liver disease rats. Methods:SD rats were divided into 7 groups:blank control group,fatty liver model group,simvastatin group (7.2 mg/kg) ,Gynostemma pentaphyilum group (16.2 mg/kg) , high dose (40 g/kg) .middle dose (20 g/kg) and low dose (10 g/kg) of AC groups. All rats except blank control group were fed with high fat diet for the first 3 weeks, then treated with different conditions as previously mentioned for the next 3 weeks while keep on feeding with high fat diet. At the 43rd day,the abdominal aortic blood was collected for measuring the serum concentration of AST, ALT,TC, TG,HDL-C,LDL-C,and liver tissues were taken to make pathological sections for observation by optical microscope or were prepared for scanning electronic microscope. Results:The levels of AST, ALT,TC,TG,LDL-C were obviously decreased while HDL-C were increased in fatty liver rats by AC high dose. Meanwhile the cell morphology of liver tissues and the fenestraes of LSEC were improved as well Conclusion:AC can ameliorate the levels of blood lipid in fatty liver rats and improve the pathological change of liver tissues. To some extent AC has the function of prevention and treatment of fatty liver.关键词
鸡骨草/脂肪肝大鼠/血脂/肝窦内皮细胞/窗孔Key words
Abrus cantoniensis Hance/Fatty liver disease rats/Blood lipid/Liver sinus endothelial cell/Fenestrae分类
医药卫生引用本文复制引用
张勤,蔡红兵,莫志贤,史珏,孙学刚,彭求贤,杨明会..鸡骨草防治大鼠脂肪肝的实验研究[J].中药材,2012,35(9):1450-1455,6.基金项目
国家自然科学基金(30901947) （30901947）
中国博士后科学基金特别资助项目(201003783) （201003783）
教育部"高等学校博士学科点专项科研基金"(20104433120002) （20104433120002）
