北华大学学报：自然科学版2012，Vol.13Issue(6)：648-650,3.
bFGF对慢性应激小鼠学习记忆及海马Ach含量的影响
Effects of bFGF on Learning-Memory Ability and the Content of Ach in Hippocampus in Chronic Stress Mice
李春颖 1曲娴1
作者信息
- 1. 北华大学基础医学院,吉林吉林132013
- 折叠
摘要
Abstract
Objective To investigate effects of basic fibroblast growth factor(bFGF)on the ability of learning and memory,and the content of Ach in hippocampus in chronic stress mice.Method An uncertain stress method was used for four weeks to establish the chronic stress model in mice.bFGF was injected intraperitoneally for 15 days on 15th day of the stress.The step-down test and darkness avoidance test were used to observe the effect of bFGF on learning-memory ability in the chronic stress mice.The change of Ach levels was tested with the hydroxylamine colorimetric assay.Results The results showed that the learning-memory abilities of mice in bFGF group were improved and contents of Ach in hippocampus increased.Conclusion bFGF can improve the learning-memory ability of chronic stress mice through improving the cholinergic function in hippocampus.关键词
bFGF/慢性应激/学习记忆/AchKey words
basic fibroblast growth factor/chronic stress mice/learning-memory/Ach分类
医药卫生引用本文复制引用
李春颖,曲娴..bFGF对慢性应激小鼠学习记忆及海马Ach含量的影响[J].北华大学学报：自然科学版,2012,13(6):648-650,3.
