生物灾害科学Issue(4)：385-391,7.
虎尾轮根黄酮类化合物对小鼠肝脏功能影响
Effects of Flavonoids from Uraria crinita on Liver Function in Mouse
摘要
Abstract
The isolated and purified flavonoids from Uraria crinita were added in the diets of the mouse which were as animal models.The effects of the flavonoids on mouse liver function was studied.Eighty four mouse,weight(20±2) g,were randomly divided into 6 groups,blank control group,model group,the positive control group that bifendate group(150 mg/kg),high dose of flavonoids group(450 mg/kg),medium dose of flavonoids group(300 mg/kg) and low dose of flavonoids group(150 mg/kg).All flavonoids groups of mouse were fed with the chemical for 21 continuous days.Carbon tetrachloride(CCl4) was used in the model group,and the mouse serum and liver tissue homogenates were used to the detection of the TAOC 、ALB、TP、AST、ALT、 MDA、SOD and GSHPx. The livers of mouse were removed to produce the slice.The results showed as follows:(1) The SOD,TAOC, GSHPx, ALB and TP level in the mouse treated with the all flavonoids group were significantly(P0.05) or extreme significantly(P0.01) higher than that in the mouse of the model group,and the AST,ALT and MDA level were lower.Flavonoids Uraria crinita could obviously affect on the repair of chemical liver.(2) Compared to the mouse in the model group,the liver form of the mouse treated with different doses of flavonoids from Uraria crinita had no significantly pathological changes observed with eyes.In the microstructure, the pathological damage was minor with varying degrees of recovery.So the flavonoids from Uraria crinita had a significantly protective effect on mouse liver injury induced by carbon tetrachloride.关键词
虎尾轮根黄酮/CCl4/肝脏功能/肝脏结构Key words
flavonoids/Uraria crinita/CCl4/liver function/liver structure分类
农业科技引用本文复制引用
陈秋勇,陈炳华,黄志坚..虎尾轮根黄酮类化合物对小鼠肝脏功能影响[J].生物灾害科学,2012,(4):385-391,7.基金项目
福建省2009年大学生创新性实验计划项目 （）
