摘要
Abstract
Objective: To investigate the efficacy and safety of mirtazapine in the treatment of depression. Methods: 76 patients with depression, who treated at psychological treatment and counseling outpatient of affiliated hospital of Inner Mongolia University for Nationalities from November 2007 to November 2011, were randomly divided into treatment group(38 cases) and control group(38 cases), the treatment group were treated with mirtazapine, and the control group were treated with paroxetine, the treatment course was 12 weeks. Adopting Hamilton rating scale for depression(HAMD) to assess the efficacy, rating scale for side effects(SERS) to assess side effects, the assessments were made before treatment and after treatment 2 and 12 weeks respectively. Results: HAMD and disease severity scores of the two groups before treatment had no significant difference (P〉0.05). After treatment for 2 and 12 weeks, HAMD scores of the two groups were significantly decreased compared with pretreatment(P〈O.05), and there was a significant difference between the two groups (P〈O.01); while after treatment 12 weeks, HAMD score between the two groups had no significant difference (P〉0.05). After 2 weeks treatment, adverse effects in the treatment group: appetite increase in 6 cases, dry mouth in 2 cases, lethargy in 3 cases, dizziness in 3 cases; in the control group: nausea in 8 cases, dry mouth in 6 cases, dizziness in 4 cases, hypodynamia in 4 cases, restlessness in 3 cases. The adve~e effects after 12 weeks treatment, there were 2 cases of gain weight in the treatment group, 1 case of sexual dysfunction in the control group. Conclusion: Mirtazapine has a reliable effect in treating depression with rapid effect and lighter adverse reactions.关键词
米氮平/帕罗西汀/抑郁症/对照研究Key words
Mirtazapine/Paroxetine/Depression/Control study分类
医药卫生
