肝胆胰外科杂志2013，Vol.25Issue(1)：39-43,5.
血浆K-ras基因突变检测对胰腺癌早期诊断价值的影响
Effect of detection of K-ras gene mutation on the diagnostic value in the early stage of pancreatic cancer
摘要
Abstract
Objective To systematically assess the diagnostic value of detection of K-ras gene mutation at codon 12 in pancreatic cancer. Methods Trials were located through electronic searches of the PubMed database, Embase database, CBM database and CNKI database from the date of establishment of the database to May 31st, 2012. All the data were searched by two statisticians. Meta-DiScl.4 software and Statal2.0 software were applied for statistical analysis. Results A total of ten trials were selected, 690 patients were involved. The heterogeneity was found in these trials except for threshold. A meta-analysis of PCR-RFLP subgroup was performed. In PCR-RFLP group, sensitivity and specificity were 0.714 (95% Cl: 0.649-0.773) and 0.868 (95% CI: 0.781-0.930) respectively, area under curve (AUC) of summary receiver operator characteristic curve (SROC) was 0.8544 and Q* index was 0.7853. Conclusion The current evidence shows that the diagnostic value of detection of K-ras gene mutation at codon 12 in pancreatic cancer has moderate effect. It is still inadequate as a separate early diagnostic marker; however, it can be used as an important complement to pancreatic cancer early diagnosis test and an alternative screening method of early diagnosis of pancreatic cancer.关键词
胰腺肿瘤/K-ras/早期诊断/Meta分析Key words
pancreatic neoplasm/ K-ras/ early diagnosis/ Meta-analysis分类
医药卫生引用本文复制引用
武文,陈炯,杨仁保,周杭城,陈龙江,胡立威..血浆K-ras基因突变检测对胰腺癌早期诊断价值的影响[J].肝胆胰外科杂志,2013,25(1):39-43,5.基金项目
国家自然科学基金资助项目(81071985) （81071985）
安徽省国际科技合作计划项目(1008010038) （1008010038）
安徽省科技攻关计划资助项目(11010402172) （11010402172）
安徽省教育厅自然科学研究项目(KJ2008A164). （KJ2008A164）
