国际医药卫生导报2013，Vol.19Issue(1)：21-24,4.DOI:10.3760/cma.j.issn.1007-1245.2013.01.008
国产注射用比伐卢定对大鼠血栓模型血小板活化功能的影响
Effect of domestic bivalirudin on platelet activation function in rat model of thrombus
陈伟宏 1吴苏武 1张淇钏 1向定成2
作者信息
- 1. 515031 汕头市中心医院重症医学科
- 2. 510010 广州军区广州总医院心内科
- 折叠
摘要
Abstract
Objectives To explore the effect of domestic bivalirudin on platelet activation function in rat model of carotid artery thrombosis.Methods A rat model of common carotid artery thrombosis was established.The rats were then randomized to control group (n =6),model group (n =10),domestic bivalirudin plus urokinase group (B&UK,n =10),and heparin plus urokinase group (H&UK,n =10).GMP-140 content and thrombus weight were detected before and after treatment.Results As compared with the model group,thrombus weight was obviously reduced in B&UK group and H&UK group.There was no significant difference in thrombus weight between B&UK group and H&UK group.GMP-140 content was remarkably greater in the model group,H&UK group,and B&UK gourp than in the control group.After treatment,GMP-140 content was significantly increased in H&UK gourp but obviously reduced in B&UK gourp.Conclusions Domestic bivalirudin can effectively inhibit formation of thrombosis in the rat model.As compared to heparin,domestic bivalirudin inhibits platelet activation function and platelet aggregation.During inhibition of thrombus formation,domcstic bivalirudin has more effects on platelet activation function.关键词
比伐卢定/肝素/颈动脉血栓形成/大鼠/血小板活化Key words
Bivalirudin/Heparin/Carotid arterial thrombosis/Rat/Platelet activation function引用本文复制引用
陈伟宏,吴苏武,张淇钏,向定成..国产注射用比伐卢定对大鼠血栓模型血小板活化功能的影响[J].国际医药卫生导报,2013,19(1):21-24,4.
