激光生物学报2013，Vol.22Issue(1)：69-73,5.DOI:10.3969/j.issn.1007-7146.2013.01.011
IL-12对巨细胞病毒DNA疫苗免疫增强作用的研究
Adjuvant Effect of IL-12 on CMV IE1 DNA Vaccine
摘要
Abstract
Interleukinl2 is mainly concerned with cellular immune response, and is also an important factor in immune regulation. In this study, the adjuvant effect of IL-12 on CMV IE1 DNA vaccine was explored in BALB/c mice. Mice were immunized two times with DNA vaccine alone or plus IL-12 DNA. After immunization, mice were challenged with lethal dose of homologous virus. The induced cellular immune responses, survival rates, weight loss and organ residue virus titers of mice after challenge were detected to evaluate the adjuvant potency of IL-12. The results showed that, compared with DNA vaccine alone, IE1 plus IL-12 DNAs induced higher production of IFN-γ secreting lymphocytes in spleen of mice and significantly increased survival rate of the mice.关键词
IL-12/即刻早期基因1/巨细胞病毒/DNA疫苗Key words
IL-12/ IE1/ Cytomegalovirus/ DNA vaccine分类
医药卫生引用本文复制引用
滕勇,黄超洋,李小曼,谢震渊,常海艳..IL-12对巨细胞病毒DNA疫苗免疫增强作用的研究[J].激光生物学报,2013,22(1):69-73,5.基金项目
湖南省科技厅项目(2008TP4033-2) （2008TP4033-2）
