实用医学杂志2012，Vol.28Issue(24)：4082-4085,4.DOI:10.3969/j.issn.1006-5725.2012.24.019
2型糖尿病患者血清25-羟维生素D3浓度与下肢血管病变的关系
Relationship between serum 25-hydroxyvitamin D3 concentration and lower-extremity peripheral arterial disease in type 2 diabetic patients
刘金霞 1张才田1
作者信息
- 1. 211400 江苏省仪征市人民医院内分泌科
- 折叠
摘要
Abstract
Objective To investigate the relationship between 25- hydroxyvitamin D3 (25(OH)D3) and lower-extremity peripheral arterial disease (PAD) in type 2 diabetic (T2DM) patients. Methods A total 105 T2DM and 50 non-diabetic healthy controls were enrolled in this study. All the diabetic patients were randomized into 2 groups [PAD group (n = 49) and Non-PAD group (n = 56)] according to whether with PAD. Routine biochemical indexes were determined. Serum 25 (0H)D3 concentration was determined by ELISA. Lower extremity vascular was measured with Doppler ultrasound in all subjects. Results Serum 25 (0H)D3 concentration decreased significantly in patients with T2DM, and specially in PAD (P < 0.05). The result of Pearson's correlation analysis showed that PAD was positively correlated with age, smoking, duration of diabetes, BMI, HbAlc, CRP and LDL-C (r = 0.56 = 0.16, P < 0.05), but was negatively correlated with serum 25 (OH) D3 concentration (r = -0.49, P < 0.01). Low serum 25 (0H)D3 concentration was an independent risk factor for PAD based on multivariate regression analysis (p = -0.37, P < 0.01). Conclusion Serum 25(OH)D3 concentration was strongly and independently associated with PAD in patients with T2DM.
关键词
糖尿病,2型/维生素D/超声检查,多普勒Key words
Type 2 diabetes/25-hydroxyvitamin D/Peripheral arterial disease引用本文复制引用
刘金霞,张才田..2型糖尿病患者血清25-羟维生素D3浓度与下肢血管病变的关系[J].实用医学杂志,2012,28(24):4082-4085,4.
