新医学2013，Vol.44Issue(2)：79-81,3.DOI:10.3969/g.issn.0253-9802.2013.02.001
异位脂肪与胰岛素抵抗
Ectopic fat and insulin resistance
邱靖雅 1傅晓英 1赵红莉1
作者信息
- 1. 510120广州,广东省第二人民医院内分泌科
- 折叠
摘要
Abstract
Ectopic fat is an important cause of insulin resistance. The cause for ectopic fat storage is largely unkown, failure of fat cell proliferation, mitochondrial function and fat oxidation, endocrine hypothesis, and alterations in CD36 content in adipose tissue, muscle, and presumably liver might all contribute to the association between ectopic fat distribution and metabolic disease. Endoplasmicreticulum stress and adipokines have roles in the pathogenesis of insulin resistance in liver and skeletal muscle. However, these do not change in lean insulin-resistant young and elderly individuals. In muscle and liver, the intracellular accumulation of lipids-namely, diacylglyc-erol-triggers activation of novel protein kinases C with subsequent impairments in insulin signalling. This unifying hypothesis accounts for the mechanism of insulin resistance in obesity, type 2 diabetes, lipodystrophy, and ageing.关键词
异位脂肪/胰岛素抵抗Key words
Ectopic fat/Insulin resistance引用本文复制引用
邱靖雅,傅晓英,赵红莉..异位脂肪与胰岛素抵抗[J].新医学,2013,44(2):79-81,3.
