中国临床心理学杂志2013，Vol.21Issue(1)：51-53,3.
5-羟色胺2A受体基因多态性与抗抑郁药物治疗反应的关联研究
Association Study of 5-HT2A Receptor Gene Polymorphisms with Antidepressants Treatment Response
摘要
Abstract
Objective: To investigation the association between 5-HT2A receptor gene rs6311 polymorphism and antidepressants treatment response of the Han nationality in China. Methods: 121 major depressive disorder patients who met DSM-Ⅳ criterion were given antidepressant drugs for six weeks (escitalopram、paroxetine). 5-HT2A receptor gene rs6311 polymorphism was genotyped by the ligase detection reaction. Results:①The frequencies of T allele and TT genotype of rs6311 were higher in non-responder group than that in responder group(P<0.05). ②The HAMD decreasing score and decreasing score rate of the patients with TT genotype of rs6311 were lower than those with CC genotype of rs6311 (P<0.05). Conclusion: The rs6311 of 5-HT2A receptor gene may be related with the treatment response to SSRIs. T allele and TT genotype is likely to be a predictive factor of the worse treatment response to SSRIs.关键词
抗抑郁药物疗效/5-HT2A受体/基因Key words
Antidepressant response/ 5-HT2A receptor/ Gene分类
医药卫生引用本文复制引用
杨栋,赵靖平,喻妍,吴仁容..5-羟色胺2A受体基因多态性与抗抑郁药物治疗反应的关联研究[J].中国临床心理学杂志,2013,21(1):51-53,3.基金项目
国家十五攻关课题(2004DA7210A21) （2004DA7210A21）
