中国临床药理学杂志2013，Vol.29Issue(2)：94-97,4.
STAT6基因多态性与新疆人群变应性鼻炎的关联
Association between single nucleotide polymorphisms of STAT6 and allergic rhinitis in Xinjiang of China
摘要
Abstract
Objective To investigate the prevalence of allergic rhinitis (AR) and the effect factors in North and South Xinjiang. To study the polymorphism of signal transduction and activator of transcription 6 ( STAT6) gene and the relationship between STAT6 Tag SNPs and allergic rhinitis. Methods Cross - sectional epidemiological study was carried out, and the questionnaires, nasal examination and nasal mucous membrane pathological examination were used to diagnose the prevalence of allergic rhinitis. The relevant factors were analyzed by using the multivariate Logistic regression analysis. Results Among the investigated 4254 cases, 644 cases of allergic rhinitis were diagnosed, the total prevalence rate was 15. 1% , and the prevalence rate in Uigur population was 12. 8% , which was less than that in Han (26. 1% ,P <0. 01). The differences of distribution frequencies of genotypes and allelic genes (rs703817) between AR group and control group were statistically significant ( P < 0. 05 ). Conclusion The prevalence rate of allergic rhinitis is much more popular and there is a significant ethnic distribution difference in Xinjiang of China. The STAT6 rs703817A/G may be associated with allergic rhinitis in Uygur.关键词
变应性鼻炎/患病率/STAT6/基因多态性/维吾尔族Key words
allergic rhinitis/ prevalence/ signal transducer and activator of transcription 6/ polymorphism/ Uygur分类
医药卫生引用本文复制引用
戴江红,姜孝芳,孙勇,杨清,刘福太,张清泉,穆尼热,高丽..STAT6基因多态性与新疆人群变应性鼻炎的关联[J].中国临床药理学杂志,2013,29(2):94-97,4.基金项目
新疆维吾尔自治区自然科学基金资助项目(200821136) （200821136）
国家自然科学基金资助项目(30960415) （30960415）
