中国临床药理学杂志2013，Vol.29Issue(2)：121-123,3.
右美托咪啶对瑞芬太尼抑制切皮体动反应量效关系的影响
Effect of dexmedetomidine on relationship of remifentanil dose and inhibition of body movement following skin incision
陈正 1杭黎华 1吴进 1邵东华1
作者信息
- 1. 江苏大学附属人民医院麻醉科,江苏 镇江212002
- 折叠
摘要
Abstract
Objective To evaluate the effect of dexmedetomidine on relationship of remifentanil dose and inhibition of body movement following skin incision. Methods One hundred and fifty patients scheduled for mammary neoplasms surgery were randomly allocated to three groups; remifentanil group (group R) and dexmedetomidine 0. 5 μg · kg-1 + remifentanil ( group D1 R) and dexmedetomidine 1.0 μg · kg -1 + remifentanil (group D2R) (50 in each). Dexmedetomidine 0.5 and 1.0 μg · kg-1 and saline were intravenously infused for 15 minutes in group D1R, D2R and R, respectively. Patients in each group were randomly assigned to five subgroups (10 in each). Remifentanil was effect - site target - controlled infused following completion of dexmedetomidine and saline infusion and the concentration was set according to different subgroups. Propofol was effect - site target - controlled infused and the concentration was set at 3 mg · L-1 in all patients of three groups when remifentanil was administered. Three minutes after remifentanil and propofol administration, a 3 cm incision was made by surgeon and body movement was judged. By applying probit analysis, the effect - site concentration of remifentanil at which 5% ( EC5 ) , 50% ( EC50) and 95% (EC95) of patients didn't show body movement during skin incision for each group were calculated. Results The EC5, EC50 and EC95 of remifentanil in group D1 R and D2R were significantly lower than group R (P <0. 0167). The EC5, EC5Oand EC95 of remifentanil in group D2R were significantly decreased compared to group D1R (P <0. 0167). Conclusion Dexmedetomidine attenuate remifentanil dose for preventing body movement in a dose - depended matter.关键词
右美托咪啶/瑞芬太尼/体动反应/量效关系Key words
dexmedetomidine/ remifentanil/ body movement/ dose - response relationship分类
医药卫生引用本文复制引用
陈正,杭黎华,吴进,邵东华..右美托咪啶对瑞芬太尼抑制切皮体动反应量效关系的影响[J].中国临床药理学杂志,2013,29(2):121-123,3.
