中国人兽共患病学报2013，Vol.29Issue(3)：267-273,7.DOI:10.3969/cjz.j.issn.1002-2694.2013.03.012
两株B型流感病毒的基因组序列分析
Genome sequence analysis on two strains of influenza B virus
摘要
Abstract
To investigate genetic characterization of two influenza B virus strains , the complete genomes were sequenced and analyzed . Phylogenetic analysis of the whole genomes revealed that two strains were classified into the Yamagata-like clade. Comparison of genome sequences of strain CXI, CX2 and other vaccines (B/Florida/4/2006 , B/Brisbane/60/2008 , and B/Malaysia/2506/2004) showed that these influenza B viruses shared higher homology . The HA gene was 89 .7% to 97 .3% in homology , and NB gene was 95 .4% to 98 .4% in homology . However , phylogenetic analysis of these two strains with a WHO recommended vaccine strain (B/Florida/4/2006) showed that 11 variations in amino acid occurred on its HA protein . Meanwhile , the N131K mutation in HA may impact its antigenicity , and the S198N mutation in NB may affect the sensitivity of NA inhibitor . These data indicated a close evolutionary relationship between these two influenza B virus strains despite minor varia -tions on certain genes of strains in the same clade .关键词
B型流感病毒/基因序列/进化树Key words
influenza B virus / gene sequence/ phylogenetic tree分类
医药卫生引用本文复制引用
岳秀芳,武艳丽,王铁成,杨松涛,黄耕,高玉伟,胡桂学,夏咸柱,于志君,朱晓文,刘红,李硕,范宝静,王世申,吴静..两株B型流感病毒的基因组序列分析[J].中国人兽共患病学报,2013,29(3):267-273,7.基金项目
吉林省卫生厅科研课题(2009zc017)资助 （2009zc017）
