首页|期刊导航|中华医学杂志（英文版）|Transmission of extensively drug-resistant and multidrug resistant Mycobacterium tuberculosis in families identified by genotyping
中华医学杂志（英文版）2013，Vol.126Issue(3)：521-525,5.DOI:10.3760/cma.j.issn.0366-6999.20121366
Transmission of extensively drug-resistant and multidrug resistant Mycobacterium tuberculosis in families identified by genotyping
Transmission of extensively drug-resistant and multidrug resistant Mycobacterium tuberculosis in families identified by genotyping
摘要
Abstract
Background Diagnosis and appropriate treatment of multidrug-resistant tuberculosis (MDR-TB) remain major challenges.We sought to elucidate that persons who share a household with drug resistance tuberculosis patients are at high risk for primary drug resistance tuberculosis and how to prevent these outbreaks.Methods We used 12-locus mycobacterial interspersed repetitive unit and 7-locus variable-number tandem repeat to identify household transmission of extensively drug resistant and multiple drug resistant Mycobacterium tuberculosis in three families admitted in Shanghai Pulmonary Hospital affiliated with Tongji University.Drug susceptibility tests were done by the modified proportion method in the MGIT 960 system in the same time.Clinical data were also obtained from the subjects' medical records.Results All of the six strains were defined as Beijing genotype by the deletion-targeted multiplex PCR (DTM-PCR) identification on the genomic deletion RD105.Strains from family-1 had the same minisatellite interspersed repetitive unit (MIRU) pattem (232225172531) and the same MIRU pattern (3677235).Strains from family-2 had the same MIRU pattern (2212261553323) and the same MIRU pattern (3685134).Strains from family-3 did not have the same MIRU pattern and they differed at only one locus (223326173533,223325173533),and did not have the same VNTR pattern with two locus differed (3667233,3677234).Conclusions Household transmission exists in the three families.A clear chain of tuberculosis transmission within family exists.Tuberculosis susceptibility should be considered when there is more than one tuberculosis patients in a family.Household tuberculosis transmission could be prevented with adequate treatment of source patients.关键词
Mycobacterium tuberculosis/extensively drug-resistant tuberculosis/household transmission/genotyping/Beijing genotype strainKey words
Mycobacterium tuberculosis/extensively drug-resistant tuberculosis/household transmission/genotyping/Beijing genotype strain引用本文复制引用
YAN Li-ping,QIN Lian-hua,ZHANG Qing,SUN Hua,HAN Min,XIAO He-ping..Transmission of extensively drug-resistant and multidrug resistant Mycobacterium tuberculosis in families identified by genotyping[J].中华医学杂志（英文版）,2013,126(3):521-525,5.基金项目
This study was funded by the National Great Research Program of China (No.2008zx 10003-015).Conflict of interests:none. （No.2008zx 10003-015）
