中国中西医结合杂志2013，Vol.33Issue(2)：205-207,3.
血必净注射液对多器官功能障碍综合征的临床作用研究
Treatment of Multiple Organ Dysfunction Syndrome by Xuebijing Injection: a Clinical Research
摘要
Abstract
Objective To observe the effects and mechanisms of Xuebijing Injection (Ⅺ) on multiple organ dysfunction syndrome (MODS) patients. Methods Recruited were 76 MODS patients at ICU, Zhejiang Provincial Quhua Hospital from February 2009 to September 2011. They were randomly assigned to the control group (36 cases) and the treatment group (40 cases). All patients received conventional treatment. Those in the treatment group were intravenously injected with Ⅺ (prepared by adding 100 mL Ql in 100 mL normal saline), twice daily for seven successive days. The APACHE Ⅱ score, SOFA score, serum procalcitonin (PCT), tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6) and 10 (IL-10) of the two groups were observed in the two groups before treatment, at 3 days and 7days after treatment. The ICU stay time and the 28-day mortality were compared between the two groups. Results After seven days of treatment, the APACHE Ⅱ score, SOFA score, TNF-α, IL-6, IL-10, and PCT significantly decreased in the treatment group, showing statistical difference when compared with the control group at the same time point (P<0.05). The 28-day mortality, the ICU stay time, APACHE Ⅱ score, and SOFA score decreased more significantly in the treatment group than in the control group, showing sstatistical difference (P <0.05). Conclusion Ⅺ could significantly reduce the ICU stay time of MODS patients, and its mechanisms might be correlated to regulating inflammatory reactions.关键词
血必净注射液/炎症反应/脓毒症/多器官功能障碍综合征Key words
Xuebijing Injection/ inflammation/ sepsis/ multiple organ dysfunction syndrome引用本文复制引用
方凯,王晓玲..血必净注射液对多器官功能障碍综合征的临床作用研究[J].中国中西医结合杂志,2013,33(2):205-207,3.基金项目
浙江省衢州市科技资助项目(No.20111096) （No.20111096）
