中国中西医结合杂志2013，Vol.33Issue(2)：252-255,4.
金匮肾气丸对肾阳虚小鼠睾丸组织端粒酶活性的促进作用
Acceleration of Jingui Shenqi Pill on the Testis Telomerase Activity in Mice of Shen-yang Deficiency
摘要
Abstract
Objective To explore the effects of Jingui Shenqi Pill (JSP) on the testis telomerase activity in mice of Shen-yang deficiency syndrome (SYDS). Methods The SYDS model was prepared in 30 mice by over-fatigue and sexual overstrain. They were randomly divided into the model group and the JSP group, 15 in each group. Another 15 normal male mice were selected as the normal group. Mice in the normal group were fed routinely, with distilled water administered intragastrically at the daily dose of 0.1 mL/10 g. Mice in the model group were also administered intragastrically with distilled water at the daily dose of 0.1 mL/10 g while modeling establishment. Mice in the treatment group were administered intragastrically with JSP suspension at 0.1 mL/10 g (the concentration was 0.241 g/mL). The intervention lasted for 4 weeks. Four weeks later, the testis telomerase activity was detected in the three groups by ELISA. Results The SYDS model was replicated successfully by over-fatigue and sexual overstrain. JSP could improve the signs of mice of SYDS. Compared with the normal group, the activity of testis telomerase decreased in the model group (P <0.01). Compared with the model group, the testis telomerase activity markedly increased in the treatment group (P <0.01). Conclusions The testis telomerase activity in mice of SYDS caused by over-fatigue and sexual overstrain obviously decreased, when compared with that in mice of the normal group. JSP could recover its activity.关键词
金匮肾气丸/肾阳虚/睾丸组织端粒酶活性Key words
Jingui Shenqi Pill/ Shen-yang deficiency/ testis telomerase activity引用本文复制引用
许翠萍,朱庆均,宋洁,李震,张丹..金匮肾气丸对肾阳虚小鼠睾丸组织端粒酶活性的促进作用[J].中国中西医结合杂志,2013,33(2):252-255,4.基金项目
国家自然科学基金重大研究计划资助项目(No.90209014) （No.90209014）
