郑州大学学报（工学版）2013，Vol.34Issue(1)：62-65,69,5.DOI:10.3969/j.issn.1671-6833.2013.01.015
去氢表雄酮的生物转化、衍生物合成及细胞毒活性研究
Biotransformation of Dihydroepiandrosterone and the Synthesis and Cytotoxic Activities of the16-Benzylidene Derivatives
摘要
Abstract
Dihydroepiandrosterone ( DHEA ) is one important bioactivity compound and one important intermediate of steroid drugs. It is for the first time to report the biotransformation of DHEA by Mucor circinelloides and two products was obtained. Furthermore, the 16-benzylidene derivatives were synthesized by Claison -Schimidt reaction. The cytotoxic evaluation showed that these derivatives had better activity than the parent compound.关键词
去氢表雄酮/卷枝毛霉/7-羟基化/16-苯亚甲基衍生物/细胞毒活性Key words
dihydroepiandrosterone/Mucor circinelloides/7-hydroxylation/16-benzylidene derivatives/cytotoxic activity分类
医药卫生引用本文复制引用
单丽红,乔星,李央,张璐珈,焦凯,刘宏民..去氢表雄酮的生物转化、衍生物合成及细胞毒活性研究[J].郑州大学学报（工学版）,2013,34(1):62-65,69,5.基金项目
国家自然科学基金资助项目(81172937) （81172937）
