北京大学学报（医学版）2013，Vol.45Issue(1)：27-32,6.DOI:10.3969/j.issn.1671-167X.2013.01.007
牙周基础治疗对2型糖尿病伴慢性牙周炎患者血糖代谢指标及血清生化指标的影响
Effect of periodontal therapy on metabolic control and serum biochemical markers in subjects with type 2 diabetes and chronic periodontitis
摘要
Abstract
To investigate the effect of periodontal therapy on periodontal clinical index, metabolic control and serum biochemical markers in subjects with type 2 diabetes and chronic periodontitis comprehensively. Methods; Forty patients with type 2 diabetes and chronic periodontitis were enrolled, and periodontal clinical parameters, HbAlc, fasting blood glucose (FBG) and serum biochemical markers were tested at baseline and 3 months after initial periodontal therapy. Results; The periodontal clinical parameters (PLI, BI,PD,CAL and BOP) improved significantly 3 months after initial periodontal therapy (P<0. 001). The HbAlc also decreased statistically (P =0.014) , while there was no change in venous fasting blood glucose. Other serum biochemical markers changed significantly including serum phosphor increased, calcium-phosphorus ratio decreased, triglyceride decreased, Apo Al increased, lipoprotein a decreased, and serum total bilirubin increased. Conclusion; The initial periodontal therapy can significantly improve periodontal clinical parameters and HbAlc control, but the effect on venous fasting blood glucose was not revealed yet. In addition, initial periodontal therapy can also intervene serum phosphorus,calcium-phosphorus ratio, and the metabolism of lipid.关键词
糖尿病,2型/牙周炎/血红蛋白A,糖基化/生物学标记/血清Key words
Diabetesmellitus, type 2/ Periodontitis/ Hemoglobin A, glycoysylated/ Biological markers/ Serum分类
医药卫生引用本文复制引用
徐菁玲,孟焕新,李峥,李凤云,张琳..牙周基础治疗对2型糖尿病伴慢性牙周炎患者血糖代谢指标及血清生化指标的影响[J].北京大学学报（医学版）,2013,45(1):27-32,6.基金项目
"十一五"国家科技支撑计划(2007BAI18B02)、卫生部临床学科重点项目(2010-2012)、首都医学发展科研基金(2009-2033)和北京大学第三医院院中青年骨干基金(79494-01)资助 （2007BAI18B02）
