长春中医药大学学报2013，Vol.29Issue(1)：10-13,4.
艾炷灸对兔动脉粥样硬化斑块稳定性物质基质金属蛋白酶-2、9mRNA的影响
Effect of Direct Moxibustion on mRNA Expression of Matrix Metalloproteinases-2,9 in Artherosclerosis Plaques of Rabbits
摘要
Abstract
Object: To observe the effect of direct moxibustion to mRNA expression of matrix metaLLoproteinases-2,9 (MMP-2, MMP-9) in artherosclerosis (AS) plaques of rabbits, to explore the effect of direct moxibustion to the stability of artherosclerosis plaques of rabbits. Method: 60 New Zealand rabbits were randomly allocated to blank, model, direct moxibustion, western medicine groups. 15 cases in each group. Expect blank group,the other groups were feeded by high-fat diet. The mRNA expression of MMP-2, MMP-9 in the atherosclerotic plaques of rabbits were detected by the method of in situ hybridization . Result: compared with model group, the expression of MMP-9 in direct moxibustion group and wesern medicine group had statistical significance( P < 0.05, P < 0.01) ; the expression of MMP-2 in wesern medicine group had statistical significance(P < 0.01); The expressions of MMP-2 in direct moxibustion group had not statistical significance(P > 0.05). Conclusion: direct moxibustion can reduce MMP-9 expression in the atherosclerotic rabbit.关键词
艾炷灸/动脉粥样硬化/基质金属蛋白酶-2/9mRNAKey words
Direct moxibustion/ Artherosclerosis/Matrix metalloproteinases 2/9mRNA分类
医药卫生引用本文复制引用
章海凤,常小荣,刘密,岳增辉,谢辉,刘未艾..艾炷灸对兔动脉粥样硬化斑块稳定性物质基质金属蛋白酶-2、9mRNA的影响[J].长春中医药大学学报,2013,29(1):10-13,4.基金项目
国家自然科学基金课题资助(编号:30973802) （编号:30973802）
湖南省科技计划项目(2011SK3095) （2011SK3095）
湖南省中医药科研计划课题(2010101) （2010101）
长沙市科技计划重点项目(K1005020-31). （K1005020-31）
