长春中医药大学学报2013，Vol.29Issue(1)：28-30,3.
木芙蓉叶提取物抗病毒作用实验研究
Antiviral Actions of the Extracts of Hibiscus Mutabilis L.
摘要
Abstract
Objective: To investigate the inhibitory effect on extracts of the leaf of hibiscus mutabilis L. in vitro and vivo. Method: The inhibitory cytopathic effects (CPE) of extracts of the leaf of hibiscus mutabilis L.observed by HEK-293 cell culture infected by RSV,Flu A and HPIVs,and use therapeutic index(TI)as an index;to observe inhibitory effect on extracts of the leaf of hibiscus mutabilis L. in vivo, the experiment were done by calculated the lung index and observed the pathological change of the mice which were given extracts of the leaf of hibiscus mutabilis L. infected with RSV. Result: The extracts of the leaf of hibiscus mutabilis L.has an inhibiting ability to RSV,Flu A and HPIVs in different degrees in vitro; in vivo, the extracts has the inhibitory effect, and showed a concentration - dependent response in inhibiting RSV. Conclusion : The extracts of the leaf of hibiscus mutabilis L. has the marked inhibitory pharmacological activity in vitro and vivo.关键词
木芙蓉叶提取物/抗病毒/病变效应/治疗指数/肺指数/小鼠Key words
Extracts of the leaf of hibiscus mutabilis L. / ntiviralactions/ Cytopathic effect( CPE) / Therapeutic index (TI)/ The lung index/ Mouse分类
医药卫生引用本文复制引用
张丽,周长征..木芙蓉叶提取物抗病毒作用实验研究[J].长春中医药大学学报,2013,29(1):28-30,3.
