高电压技术2013，Vol.39Issue(1)：156-162,7.DOI:10.3969/j.issn.1003-6520.2013.01.023
极低频电磁场曝露对大鼠认知功能和海马形态结构的影响
Effects of Extremely Low Frequency Electromagnetic Fields Exposture on Cognitive Function and Hippocampal Morphology of Rats
摘要
Abstract
In order to define the neurobiological effects of extremely low frequency electromagnetic fields (ELF-EMFs), the cognitive function and hippocampal morphology of rats exposed to ELF-EMFs were experimentally investigated. Some male Wistar rats were exposed to ELF-EMFs (50 Hz, 400 μT, <1 V/m) for 60 d firstly, meanwhile these body weights were recorded weekly. After the exposure, the cognitive function, hippocampal morphology and content of Nissl bodies were measured by Morris water maze test, light/electronic microscopy and toluidine blue staining image analysis, respectively. The results showed that, during the exposure, the growth rate of rat body weight significantly decreased, but it restored after stopping exposure for 2 weeks. Immediately after the exposure being stopped, the average escape latency was significantly prolonged (P<0. 01), but it restored 7 d later. Part of the rat hippocampal neurons showed characteristic morphological changes of degeneration and apoptosis, and damages in synaptic structural, and the content of Nissl bodies reduced(P<0. 05) ; however, the lesions mentioned above recovered 15 d later and even restored 30 d later. It is concluded that the ELF-EMFs exposure (50 Hz, 400 μT, 60 d) can decrease the growth rate of body weight, cause cognitive dysfunctions, damage hippocampal formations, and reduce the content of Nissl bodies. However, these effects occur mainly in the early stage after the exposure being stopped, thus they were characterized by short duration and recoverability.关键词
极低频电磁场(ELF-EMFs)/海马神经元/认知功能/形态结构/尼氏体含量/神经突触/大鼠体质量Key words
extremely low frequency electromagnetic fields (ELF-EMFs)/ hippocampal neurons/ cognitive function/ morphology/ the content of the Nissl bodies/ neurons synapses/ weight of rats引用本文复制引用
刘肖,左红艳,王德文,彭瑞云,王水明,徐新萍..极低频电磁场曝露对大鼠认知功能和海马形态结构的影响[J].高电压技术,2013,39(1):156-162,7.基金项目
国家自然科学基金(51037006). （51037006）
