国际病理科学与临床杂志2013，Vol.33Issue(1)：37-41,5.DOI:10.3969/j.issn.1673-2588.2013.01.006
晚期非小细胞肺癌中β-tubulin Ⅲ表达水平对化学治疗敏感性的影响
Effect of beta-tubulin Ⅲ expression levels on chemotherapy sensitivity for advanced non-small cell lung cancer
摘要
Abstract
Objective: To analyze the relation between β-tubulin Ⅲ expression level and chemosensitivity in non-small cell lung cancer (NSCLC). Methods: The patients were divided into a control group and a genotype group with a proportion of 1:2. The control group received the treatment of gemcitabin and cisplatin, while the genotype group received individual therapy according to the level of ERCC1 and RRM1. The correlation between β-tubulin Ⅲ expression level and chemosensitivity in NSCLC was analyzed. Results:β-Tubulin Ⅲ expression was detected in all patients in the genotype group. Compared with the genotype group (47.5%), efficiency in the control group (37.5%) was not significantly different. Efficiency in patients with low expression of β-tubulin Ⅲ was significantly higher than that of patients with high expression of β-tubulin Ⅲ (55.1% vs 36.7%, P<0.05). Conclusion: In advanced NSCLC subtypes, patients with low expression of β-tubulin Ⅲ have good therapeutic effect. High β-tubulin Ⅲ expression may indicate resistance to docetaxel.关键词
非小细胞肺癌/β-tubulin Ⅲ,ERCC1基因/RRM1基因Key words
non-small cell lung cancer/ β-tubulin Ⅲ/ ERCC1 gene/ RRM1 gene引用本文复制引用
陈佳,何松,王淼舟,郭燕,张晓东,吉志固,朱亚芳,陆俊国,陶玉..晚期非小细胞肺癌中β-tubulin Ⅲ表达水平对化学治疗敏感性的影响[J].国际病理科学与临床杂志,2013,33(1):37-41,5.基金项目
江苏省卫生厅面上项目(H200867). （H200867）
