中医学报2013，Vol.28Issue(3)：375-377,后插1,4.
神经肽Y、血管活性肠肽在脑外伤合并股骨骨折大鼠模型骨痂中的表达及意义
Expression and Significance of Callus of Neuropeptide Y,Vasoactive Intestinal Peptide in Cerebral Trauma with Femoral Fracture in Rat Model
摘要
Abstract
Objective: To rerearch Neurpeptide and Vasoactive intestinal peptide in brain trauma with femoral fracture callus expression in a rat modle. Methods:60 male SD rats were randomly divided into 2 groups,brain trauma with femoral fracture group 30,group 30 only isolated femur fracture. In after the success of modeling respectively in seventh days, fourteenth days, twenty-first days, twenty-eighth days, thirty-fifth daysof sacrifice. Femur fracture tissues were stained by HE and immunohistochemistry. Expression of femoral fracture healing and NPY,VIP site in rat femoral fracture. Results:Traumatic brain injuryfracture group compared with simple fracture of femur farcture healing group. The results of immunohistochemical staining showed fracture healing within the outer periosteum, bone progenitor cells, chondrocytes, osteoblasts in NPY, the positive expression of VIP and simple fracture group, the difference has statistical significance (P<0.05). Conclusion; Brain injury combined with fracture callus in rats PNY,VIP have significant change. That neu-ropeptiides are involve in the regulation of the process of fracture healing.关键词
神经肽Y/血管活性肠肽/脑外伤合并股骨骨折/骨痂/大鼠模型Key words
neuropeptide Y/ vasoactive intestinal peptide/ brain trauma with femoral fracture/ callus/ rat model分类
医药卫生引用本文复制引用
郑若昆,汪贺轩..神经肽Y、血管活性肠肽在脑外伤合并股骨骨折大鼠模型骨痂中的表达及意义[J].中医学报,2013,28(3):375-377,后插1,4.
