化工进展2011，Vol.30Issue(3)：589-596,8.
二步种子溶胀法制备氯霉素分子印迹聚合物微球及其识别性能
Preparation of molecularly imprinted polymer microspheres for chloramphenicol by two-step seed swelling and its recognition performance
左华敏 1李雁 1李璐 1解新安 1熊明洲1
作者信息
摘要
Abstract
Monodisperse molecularly imprinted polymer microsphere ( MIPMs ) for chloramphenicol was prepared by two-step seed swelling using linear polystyrene emulsion as seeds, methacrylic acid (MAA) as functional monomer and ethylene glycol dimethacrylate (EDMA) as crosslinker. The influences of swelling ratio, stirring speed, ratio of water to oil, dosage of cross-linker and dispersant on the morphology, size and size distribution of the MIPMs were investigated by scanning electron microscopy ( SEM ). Furthermore, static adsorption was used to evaluate the recognition properties of the MIPMs. When the swelling ratio was 40, stirring speed was 150 r/min around, ratio of water to oil was (8: 1)-(11: 1), dosage of cross-linker was 20 mmol, dosage of dispersant was 1.2 g, a series of uniformly sized MIPMs with good dispersion were obtained. When 4 mmol MAA was used as the functional monomer, and the dosage of crosslinker was 20 mmol, the prepared MIPMs exhibited the best recognition performance, and the separation factor was up to 5.57 when thiamphenicol was chosen as the competitive molecules. Two-step seed swelling opened a simple and effective approach to preparing MIPMs in water.关键词
二步种子溶胀/分子印迹/氯霉素/微球Key words
two-step seed swelling/ molecularly imprinted/ chloramphenicol/ microspheres分类
化学化工引用本文复制引用
左华敏,李雁,李璐,解新安,熊明洲..二步种子溶胀法制备氯霉素分子印迹聚合物微球及其识别性能[J].化工进展,2011,30(3):589-596,8.
