江苏大学学报（医学版）2012，Vol.22Issue(5)：448-451,4.
左西孟旦治疗慢性心力衰竭急性失代偿患者的临床观察
Clinical observation of levosimendan on patients with acute decompensated heart failure
殷泉忠 1崔俊友 1郑若龙 1钱惠东 1李伟章 1高春恒 1易桂斌1
作者信息
摘要
Abstract
Objective: To explore the clinical efficacy and safety of levosimendan on patients with acute decompensated heart failure. Methods: One hundred patients met the inclusion criteria were randomly divided into one group with levosimendan and the other group with milrinone. Clinical efficacy, heart function , BNP and the 24 hourly urine volume, systolic pressure, LVEF, LVEDD and adverse reaction were detected before and after treatment. Results: Both efficiency and total effective rate after treatment in levosimendan group were higher than those in milrinone group (x2 - 4 · 006 and 8. 274 , P < 0. 05 ). Statistical significance of BNP, the 24 hourly urine volume and LVEF was noted in two groups after treatment( P < 0.01 ). Serum BNP levels decreased, the total 24 hourly urine volume increased and LVEF improved in levosimendan group compared with milrinone group( P <0. 01 ). During the treatment period, occurrences of adverse events in levosimendan group were lower than those in control group (x2 =1.301,P<0.05). Conclusion: Levosimendan was well tolerated and superior to milrinone for patients with decompensated heart failure refractory to conventional medications, because it was able to improve heart function and the symptoms of heart failure by alterring haemodynamic variables.关键词
左西孟旦/慢性心力衰竭/充血性Key words
levosimendan/ chronic heart failure / congestive分类
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殷泉忠,崔俊友,郑若龙,钱惠东,李伟章,高春恒,易桂斌..左西孟旦治疗慢性心力衰竭急性失代偿患者的临床观察[J].江苏大学学报（医学版）,2012,22(5):448-451,4.
