摘要
Abstract
Objective To provide more clinical evidences of triple antiplatelet drugs for the treatment of non-ST-segment elevation ACS, we explored the effects of short-term triple antiplatelet drugs to inflammatory factors and endothelial function in non-ST-segment elevation acute coronary syndrome (ACS) patients. Methods 82 non-ST-segment elevation ACS patients were divided into two groups randomly, the control group were administered dual anti platelet drugs, aspirin and clopidogrel. While the observation group were administered triple antiplatelet drugs, aspirin, clopi-dogrel and tirofiban. The changes of inflammatory factor (hsCRP 、IL-6) and the endothelium func-tion(ET-1, NO, PGI2) 48hrs after treatment were observed. Results Compared with the dual antiplatelet drugs therapy, the triple antiplatelet drugs decreased the inflammatory factor and improved the endothelium function more effectively. The main adverse effect of the antiplatelet therapy was ecchymosis in subcutaneous gingival bleeding. But the difference showed no statistical significance between the two groups. Conclusion As for the non-ST-segment elevation ACS patients, the method of triple antiplatelet drugs therapy has more effect in decreasing the inflammatory factor and improving the endothelium function. Thus it is worthy of wide clinical applications.关键词
抗血小板聚集/非ST段抬高急性冠脉综合征/炎症因子/内皮功能Key words
antiplatelet aggregation/ non-ST-elevation ACS/ inflammatory factor/ endothelium function分类
医药卫生
