实用临床医药杂志2013，Vol.17Issue(1)：37-40,4.DOI:10.7619/jcmp.201301011
抑郁症与强迫症患者治疗前后血清脑源性神经营养因子、白介素-2及白介素-6水平变化及其临床意义
The level changes of brain-derived neurotrophic factors, interleukin-2 and interleukin-6 in serum of patients with depression and obsessive-compulsive disorder before and after treatment and their clinical significance
摘要
Abstract
Objective To explore the level changes of brain-derived neurotrophic factors (BDNF), interleukin-2 (IL-2) and interleukin-6 (IL-6) in serum of patients with depression and obsessive-compulsive disorder before and after treatment and the influential factors. Methods There were 30 cases in depression group (depression patients), 30 cases in obsessive-compulsive disorder group (patients with obsessive-compulsive disorder) and 30 cases in control group. On the basis of paroxetine therapy, the psychological therapy was administered in the depression group and the obsessive-compulsive disorder group. The levels of BDNF, IL-2 and IL-6 in serum of the three groups were detected by enzyme-linked immunosorbent assay (ELISA). Before and after treatment, the scale assessment was conducted. Hamilton depression rating scale (HAMD) was applied to assess the symptoms of depression while yale-brown obsessive compulsive scale (Y-BOCS) to evaluate obsessive compulsive symptoms. The relative analysis was conducted between the levels of BDNF, IL-2 and IL-6 in serum of patients with depression and obsessive - compulsive disorder and HAMD total score, Y-BOCS total score, disease duration, age and gender. Results After treatment, serum BDNF level in the depression group significantly increased, while the levels of IL-2 and IL-6 obviously decreased, but BDNF level was still lower than that in the control group. Serum BDNF level in obsessive-compulsive disorder group conspicuously elevated, whereas IL-2 level markedly reduced, but BDNF level was still lower than that in the control group. In the depression group, serum BDNF level was associated with HAMD score negatively, while the levels of IL-2 and IL-6 in serum were related to HAMD score positively. In the obsessive-compulsive disorder group, serum BDNF level is associated with Y-BOCS score negatively, while serum IL-6 was related to Y -BOCS score positively. Conclusion BDNF, IL-2 and IL-6 can provide possible evidences for the i-dentification and diagnosis of depression and obsessive-compulsive disorder.关键词
抑郁症/强迫症/脑源性神经营养因子/白介素-2/白介素-6Key words
depression/ obsessive-compulsive disorder/ brain-derived neurotrophic factor/ interleukin-2/ interleukin-6分类
医药卫生引用本文复制引用
江鸿波,李莉欣..抑郁症与强迫症患者治疗前后血清脑源性神经营养因子、白介素-2及白介素-6水平变化及其临床意义[J].实用临床医药杂志,2013,17(1):37-40,4.基金项目
中国高校医学期刊临床专项资金(11220224) （11220224）
