摘要
Abstract
Objective To investigate the clinical effects of combination therapy of losartan and Ambrette capsule on diabetic nephropathy. Methods Fifty patients with diabetic nephropathy were randomly divided into two groups, losartan and the combination group of each of 25 patients. Losartan group received losartan, combination group losartan plus Ambrette capsule. The level of 24 h urinary protein, Urine acetyl-β-D glucosaminidase (NAG), Urine β2-microglobulin (β2-MG) and Serum creatinine was measured before and after treatment. Results The level of 24 h urinary protein, urine NAG, urine β2-MG was significantly decreased in combination group after 12-week treatment, when compared to losartan group (P<0.05), while serum creatinine not (P>0.05). In losartan group, only 24 h urinary protein decreased by losartan treatment, whilst in combination group, the levels of 24 h urinary protein, urine NAG, urine β2-MG were all decreased (P<0.05). Conclusion Combination therapy with losartan and Ambrette capsule can effectively decrease urinary protein and protect tubular function.关键词
糖尿病肾病/黄葵胶囊/氯沙坦/药物疗法/联合Key words
Diabetic nephropathy/ Ambrette capsule/ Losartan/ Drug therapy/ Combination分类
医药卫生
